| ncRNA name | TLR9 siRNA |
| ncRNA Category | siRNA |
| Disease name | Pseudomonas aeruginosa keratitis |
| Species | Mus musculus |
| Tissues/Cell_line | corneas; mouse Langerhans cell line XS52 |
| Methods | qRT-PCR, siRNA transfection and injection, ELISA, immunostaining |
| Expression pattern | associated |
| Functional description | LCs stimulated with CpG DNA and treated with TLR9 siRNA exhibited reduced TLR9, IL-1beta, and MIP-2 levels compared with controls. Finally, B6 mice treated with TLR9 siRNA showed decreases in corneal opacity, polymorphonuclear leukocyte number, IL-12 and IFN-gamma mRNA, IL-1beta, and MIP-2 protein compared with those treated with control siRNA. |
| PubMed ID | 16249500 |
| Year | 2005 |
| Title | Silencing Toll-like receptor-9 in Pseudomonas aeruginosa keratitis. |
| Drug-related ncRNA | NO |
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